Histological and histomorphometric findings of two different xenografts in maxillary sinus augmentation
INTRODUCTION
The present study aimed to compare the histological and histomorphometrical findings of new generated
bone quality for maxillary sinus grafting using either deproteinized porcine bone mineral (DPBM) and
deproteinized bovine bone mineral (DBBM).
MATERIAL & METHODS
According to sample size calculation 30 eligible maxillary sinus sites with the pre-exquisite of staged
maxillary sinus augmentation procedure consisting of a residual vertical alveolar ridge height of <5mm
were recruited. Using a randomization protocol grafting of maxillary sinus augmentation was performed
either with DPBM (Mineross XP®, Bio-Horizons, size: 0.25-1.0 mm, test group) or DBBM (Bio‐Oss®,
Geistlichpharma AG, size: 0.25-1.0 mm, control group). After a healing period of 6-7 months after
implant placement, bone core biopsies of the maxillary sinus grafts were taken in the axial direction with
a trephine bur for histological and histomorphometric analysis.
RESULTS
From the original included 26 patients with 30 maxillary sinus sites 2 patients (3 maxillary sinus)
dropped out (insufficient core biopsy) resulting in 24 patients with 27 maxillary sinus sites (13x
DPBM/14xDBBM) for histological and histomorphometrical analysis. In the statistical analyses, the test
group (DPBM) showed comparable new bone formation and residual biomaterials to the control group
(DBBM) in both histological and histomorphometric analysis. However, smaller sizes of residual
biomaterials were observed in the histological samples from the porcine testgroup compared to control
sites. Despite the use of the same sizes of both biomaterials used (0.25-1.0mm) the difference in residual
particle size let assume an ongoing degradation/resorption process of the test group material.
CONCLUSION: The results suggested that DPBM might produce comparable bone formation and
volumetric stability with DBBM in maxillary sinus grafting.
Learning objectives
- histological and histomorphometrical analysis of of new generated bone quality for maxillary sinus grafting using deproteinized porcine bone mineral
- histological and histomorphometrical analysis of of new generated bone quality for maxillary sinus grafting using deproteinized bovine bone mineral
- Comparison of both biomaterials